Review on how lifestyle changes and especially dietary habits are at the basis of chronic systemic low grade inflammation, insulin resistance and Western diseases. The authors support the hypothesis that the advent of agriculture and industrial revolutions have contributed to the introduction of some disturbing inflammatory triggers, the adverse effects of which trace back to the rapid human brain growth that occurred 2.5 million years ago. The authors conclude that getting back to Paleolithic lifestyle, under a 21st century translated form, might be the only way to resolve this conflict between environment and our ancient genome.


Ruiz-Núñez, B. (2013) Lifestyle and nutritional imbalances associated with Western diseases: causes and consequences of chronic systemic low-grade inflammation in an evolutionary context. J Nutr Biochem 24:1183-201.